This portal contains the results of multimodal RNA phenotyping and genetic analyses for 50 human tissue datasets using Pantry. It includes RNA phenotypes, covariates, cis-xQTL results from tensorQTL, and weights and associations for multimodal transcriptome-wide association study (xTWAS) results using FUSION, for six RNA modalities, for Geuvadis and 49 GTEx tissues. It also includes data for residual data-driven RNA phenotypes produced by LaDDR to supplement the knowledge-driven RNA phenotypes, as well as data for full data-driven RNA phenotypes that can be used as an alternative to knowledge-driven RNA phenotypes. The xTWAS data covers 114 traits using GWAS data from this collection.
"Multimodal analysis of RNA sequencing data powers discovery of complex trait genetics" Nature Communications 2024
Read the PaperPermanent data repository with DOI on Zenodo. Contains compressed archives of the downloadable files in this portal.
Access the DataBrowse all xTWAS hits and xQTLs for 49 human tissues from GTEx, search for a specific trait or gene, or download the data, including RNA phenotypes, covariates, xQTLs, xTWAS weights, and xTWAS hits.