RNA phenotyping and genetic analysis portal

Explore Pantry and LaDDR results across human tissues.

This portal contains multimodal RNA phenotypes, covariates, cis-xQTL results from tensorQTL, and xTWAS weights and associations generated from Geuvadis and 49 GTEx tissues.

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50 human tissue datasets

6 RNA modalities

114 GWAS traits

Knowledge-driven RNA phenotypes from Pantry are supplemented with residual data-driven phenotypes produced by LaDDR, plus full data-driven phenotypes that can be used as an alternative to knowledge-driven RNA phenotypes. The xTWAS data covers 114 traits using GWAS data from this collection.

Publications

Pantry

"Multimodal analysis of RNA sequencing data powers discovery of complex trait genetics" Nature Communications 2024

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LaDDR

LaDDR preprint describing data-driven RNA phenotype discovery.

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Code

Pantry

Pipeline code for RNA phenotyping and genetic analyses.

View GitHub

LaDDR

Python package for data-driven RNA phenotyping.

View GitHub

Datasets

Pantry

Zenodo repository with the original Pantry data at the time of publication.

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LaDDR

Zenodo repository for LaDDR phenotype and analysis data.

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Browse all xTWAS hits and xQTLs for 49 human tissues from GTEx, search for a specific trait or gene, or download the data, including RNA phenotypes, covariates, xQTLs, xTWAS weights, and xTWAS hits.